FEBS letters, 2009-11, Vol.583 (21), p.3448-3454
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Cell sex determines anoikis resistance in vascular smooth muscle cells
- Ist Teil von
- FEBS letters, 2009-11, Vol.583 (21), p.3448-3454
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2009
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2009.09.052Titel-ID: cdi_proquest_miscellaneous_734116443
- Format
- –
- Schlagworte
- 4-HNE, 4-hydroxynonenal, Actins - metabolism, androgen receptors, Animals, Anoikis, Apoptosis, Autophagy, Cell Adhesion, Cytoskeleton - metabolism, ERs, estradiol, estrogen receptors, FAK, Female, female-derived vascular smooth muscle cells, focal adhesion kinase, FVSMC, Gender, Male, male-derived vascular smooth muscle cells, Muscle, Smooth, Vascular - cytology, Muscle, Smooth, Vascular - metabolism, MVSMC, Oxidation-Reduction, p-FAK, phosphorylated focal adhesion kinase, Phosphorylation, Rats, Reactive oxygen species, ROS, scanning electron microscopy, SEM, Senescence, Sex Characteristics, ultraviolet B radiation, UVB, Vascular smooth muscle cells, VSMC