Details

Autor(en) / Beteiligte

• El Gezawi, S.
• Omar, N.
• El Rabbat, N.
• Ueda, H.
• Perrin, J.H.

Titel

Microcalorimetric and chromatographic investigations of the binding of some pyridine derivatives to cyclodextrins

Ist Teil von

• Journal of pharmaceutical and biomedical analysis, 1988, Vol.6 (4), p.399-406

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

1988

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• The binding of some pyridine derivatives to α-, β- and γ-cyclodextrins has been investigated by microcalorimetry. The strongest binding is to β-cyclodextrin, but the binding constants are of the order 10 2 M −1. The binding to β-cyclodextrin was also investigated by high performance liquid chromatography. The addition of β-cyclodextrin to the mobile phase allowed separation of molecules with similar binding constants and of racemates in the case of tropicamide.