Details

Autor(en) / Beteiligte

• Li, Xiang-Pei
• Zhang, Zheng
• Lu, Qian-Jin
• Zhang, Xue-Jun
• Zhang, Xiao-Yan
• Shen, Song-Ke
• Cheng, Yi-Lin
• Zhao, Guo-Ping
• Lin, Da
• Han, Jian-Wen
• Li, Jian
• Zuo, Xiao-Xia
• Shen, Min
• Ye, Zhi-Zhong
• Wang, Ying
• Li, Yi
• Liu, Sheng-Xiu
• Wang, Qing-Wen
• Zhu, Kun-Ju
• Zhang, Feng-Yu
• Fang, Hong
• Yang, Sen
• Zhang, Chi
• Guo, Qing
• Gao, Min
• Hu, Da-Yan
• Zhou, Fu-Sheng
• Sheng, Yu-Jun
• Huang, Jian-Lin
• Xu, Jian-Hua
• Lu, Wen-Sheng
• Zhang, An-Ping
• Zhai, Zhi-Fang
• Ma, Li
• Xiao, Feng-Li
• Lv, Yong-Mei
• Cui, Yong
• Zheng, Hou-Feng
• Zuo, Xian-Bo
• Li, Bo
• Xie, Hong-Fu
• Li, Yang
• Sun, Liang-Dan
• Deng, Dan-Qi
• Ren, Yun-Qing
• Wang, Zai-Xing
• Li, Hui
• Ye, Dong-Qing
• Zhou, Wen-Ming
• Zeng, Fan-Qin
• Zhang, Sheng-Quan
• Cai, Zhi-Ming
• Wang, Pei-Guang
• Yang, Jian-Qiang
• Low, Hui Qi
• Yang, Chun-Jun
• Liu, Jian-Jun
• Pan, Yun-Feng
• Zhang, Pei-Lian
• Du, Wen-Hui
• Zhu, Wei-Fang
• Gao, Fei
• Xu, Jin-Hua
• Quan, Cheng
• Huang, Wei
• Hu, Zhi
• Hao, Fei

Titel

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Ist Teil von

• Nature genetics, 2009-11, Vol.41 (11), p.1234-1237

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations. We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci ( ETS1 , IKZF1 , RASGRP3 , SLC15A4 , TNIP1 , 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 × 10 −25 ≤ P combined ≤ 2.77 × 10 −8 ) and confirmed seven previously reported loci ( BLK , IRF5 , STAT4 , TNFAIP3 , TNFSF4 , 6q21 and 22q11.21; 5.17 × 10 −42 ≤ P combined ≤ 5.18 × 10 −12 ). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.