Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Deprotonation Mechanism of New Antihypertensive Piperidinylmethylphenols: A Combined Experimental and Theoretical Study
Ist Teil von
The journal of physical chemistry. B, 2009-08, Vol.113 (34), p.11765-11774
Ort / Verlag
United States: American Chemical Society
Erscheinungsjahr
2009
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Four new antihypertensive piperidinylmethylphenol compounds were synthesized for their potential antihypertensive and antiarhythmic properties. The pK a values were determined experimentally, with the aid of the program SQUAD, by capillary zone electrophoresis (CZE) at T = 298.15 K and 0.015 M ionic strength (I = 0.05 M) and by UV spectrophotometry at pseudophysiological conditions (T = 310.15 K and I = 0.15 M), obtaining good agreement between the values determined with both techniques. A theoretical study was followed in order to propose a deprotonation mechanism for each compound.