Details

Autor(en) / Beteiligte

• Lees, Emma E
• Nguyen, Tich-Lam
• Clayton, Andrew H. A
• Mulvaney, Paul

Titel

The Preparation of Colloidally Stable, Water-Soluble, Biocompatible, Semiconductor Nanocrystals with a Small Hydrodynamic Diameter

Ist Teil von

• ACS nano, 2009-05, Vol.3 (5), p.1121-1128

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• We report a simple, economical method for generating water-soluble, biocompatible nanocrystals that are colloidally robust and have a small hydrodynamic diameter. The nanocrystal phase transfer technique utilizes a low molecular weight amphiphilic polymer that is formed via maleic anhydride coupling of poly(styrene-co-maleic anhydride) with either ethanolamine or Jeffamine M-1000 polyetheramine. The polymer encapsulated water-soluble nanocrystals exhibit the same optical spectra as those formed initially in organic solvents, preserve photoluminescence intensities, are colloidally stable over a wide pH range (pH 3−13), have a small hydrodynamic diameter, and exhibit low levels of nonspecific binding to cells.