Details

Autor(en) / Beteiligte

• Akerstrom, Thorbjorn C. A.
• Krogh‐Madsen, Rikke
• Petersen, Anne Marie Winther
• Pedersen, Bente Klarlund

Titel

Glucose ingestion during endurance training in men attenuates expression of myokine receptor

Ist Teil von

• Experimental physiology, 2009-11, Vol.94 (11), p.1124-1131

Ort / Verlag

Oxford, UK: The Physiological Society

Erscheinungsjahr

2009

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Interleukin-6 receptor α (IL-6Rα) expression in skeletal muscle is induced by acute exercise, mediated in part by an increased IL-6 concentration in the bloodstream. We hypothesized that endurance training would increase the density of IL-6Rα in skeletal muscle and that glucose ingestion would attenuate the effect. Nine subjects performed 10 weeks of one-legged knee-extensor training. They trained one leg (Glc-leg) while ingesting a glucose solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc-leg). Endurance training increased peak power by ∼14% and reduced the exercise-induced gene expression of IL-6 and IL-6Rα in skeletal muscle and IL-6 plasma concentration. The IL-6Rα density increased to a lesser extent in the Glc-leg, suggesting that glucose ingestion attenuates the effect of training on IL-6Rα by blunting the IL-6 response. We conclude that glucose ingestion during endurance training attenuates the increase in IL-6Rα density.