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Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle,
which results in a diminished increase in plasma IL-6. Interleukin-6 receptor α (IL-6Rα) expression in skeletal muscle is
induced by acute exercise, mediated in part by an increased IL-6 concentration in the bloodstream. We hypothesized that endurance
training would increase the density of IL-6Rα in skeletal muscle and that glucose ingestion would attenuate the effect. Nine
subjects performed 10 weeks of one-legged knee-extensor training. They trained one leg (Glc-leg) while ingesting a glucose
solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc-leg). Endurance training increased peak power
by â¼14% and reduced the exercise-induced gene expression of IL-6 and IL-6Rα in skeletal muscle and IL-6 plasma concentration.
The IL-6Rα density increased to a lesser extent in the Glc-leg, suggesting that glucose ingestion attenuates the effect of
training on IL-6Rα by blunting the IL-6 response. We conclude that glucose ingestion during endurance training attenuates
the increase in IL-6Rα density.