Details

Autor(en) / Beteiligte

• Rogakos, Vassilis
• Georgiadis, Dimitris
• Dive, Vincent
• Yiotakis, Athanasios

Titel

A Modular Rearrangement Approach toward Medicinally Relevant Phosphinic Structures

Ist Teil von

• Organic letters, 2009-10, Vol.11 (20), p.4696-4699

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• An unprecedented coupling of a P−C and a C−C bond-forming event in a practical operation was developed to access medicinally relevant phosphinic structures. The strategy relies on an Ireland−Claisen rearrangement triggered by the phospha-Michael addition of silyl phosphonites to allyl acrylates. This protocol was extended to a more versatile three-component variant that utilizes phosphinic acids, acryloyl chlorides, and allylic alcohols as starting materials.