Details

Autor(en) / Beteiligte

• Dayer, J M

Titel

The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis

Ist Teil von

• British journal of rheumatology, 2003-05, Vol.42 (suppl-2), p.ii3-ii10

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2003

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The role of the cytokine network in mediating inflammation and joint destruction in rheumatoid arthritis (RA) has been investigated extensively in recent years. Interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFα) are two pivotal proinflammatory cytokines that have been shown to contribute to the clinical manifestations of RA. The ability of IL-1 to drive inflammation and joint erosion and to inhibit tissue repair processes has been clearly established in in vitro systems and animal models. Under physiological conditions, the activity of IL-1 is balanced by IL-1 receptor antagonist (IL-1Ra). Understanding of the respective roles of IL-1 and IL-1Ra in conditions of health and disease has led to the development of a recombinant IL-1ra, anakinra (Kineret®; Amgen Inc., Thousand Oaks, CA), which offers a new therapeutic modality for RA.