Details

Autor(en) / Beteiligte

• Fedotov, Ilya V
• Fedotov, Andrei B
• Doronina, Lyubov V
• Zheltikov, Aleksei M

Titel

Enhancement of guided-wave two-photon-excited luminescence response with a photonic-crystal fiber

Ist Teil von

• Applied Optics, 2009-10, Vol.48 (28), p.5274-5279

Ort / Verlag

United States

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Photonic-crystal fiber (PCF) is shown to substantially increase the guided-wave luminescent response from molecules excited through two-photon absorption (TPA) by femtosecond near-infrared laser pulses. With only a few nanoliters of TPA-excited molecules filling airholes in a specifically designed PCF, the guided-wave two-photon-excited luminescence (TPL) signal is enhanced by more than 2 orders of magnitude relative to the maximum TPL signal attainable from a cell with the same dye excited and collected by the same PCF. Biophotonic implications of this waveguide TPL-response enhancement include fiber-format solutions for online monitoring of drug delivery and drug activation, interrogation of neural activity, biosensing, endoscopy, and locally controlled singlet oxygen generation in photodynamic therapy.