Details

Autor(en) / Beteiligte

• Tofteng, A. Pernille
• Sørensen, Kasper K.
• Conde‐Frieboes, Kilian W.
• Hoeg‐Jensen, Thomas
• Jensen, Knud J.

Titel

Fmoc Solid‐Phase Synthesis of C‐Terminal Peptide Thioesters by Formation of a Backbone Pyroglutamyl Imide Moiety

Ist Teil von

• Angewandte Chemie International Edition, 2009-09, Vol.48 (40), p.7411-7414

Ort / Verlag

Weinheim: WILEY‐VCH Verlag

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Activating an inactive bond: A new concept in synthetic peptide chemistry, backbone amide activation, proceeds through the selective conversion of a backbone amide into an imide, followed by nucleophilic acyl displacement (see scheme; Boc=tert‐butoxycarbonyl, Pg=protecting group). This methodology represents a new approach to solid‐phase synthesis of C‐terminal peptide thioesters, and may become a general tool for the synthesis of peptide thioesters.