FEBS letters, 1992-12, Vol.314 (3), p.285-288
1992
Details
- Autor(en) / Beteiligte
- Titel
- The murine NPY-1 receptor gene Structure and delineation of tissue-specific expression
- Ist Teil von
- FEBS letters, 1992-12, Vol.314 (3), p.285-288
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1992
- Link zum Volltext
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- The murine gene for the NPY-1 receptor subtype for neuropeptide Y was characterized by DNA sequencing and expression studies. It comprises three exons with a 6,400 bp 5′-untranslated and a 80 bp internal intronic sequence. The 5′-flanking region of this gene lacks TATA or CCAAT consensus sequences in the proximity to the multiple transcription initiation sites. A 1,300 bp genomic fragment of the 5′-flanking region drives the expression of the lacZ reporter gene in NG108-15 cells and primary cultured neurons but not in glial and human embryonic kidney cells. In addition, it contains consensus sequences for various transcription factors including cAMP- and glucocorticoid-responsive elements.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(92)81490-DTitel-ID: cdi_proquest_miscellaneous_73401291
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, base pair, Base Sequence, Biological and medical sciences, Cell receptors, Cell structures and functions, DNA, Fundamental and applied biological sciences. Psychology, G protein receptor, Gene expression, Gene structure, kilobases, Mice, Molecular and cellular biology, Molecular Sequence Data, Neuropeptide receptor, Neuropeptide receptors, Neuropeptide Y, NPY, Organ Specificity - genetics, piperazine-N,N′-bis[2-ethane sulphonic acid], PIPES, Promoter Regions, Genetic, Receptors, Neuropeptide Y - genetics, Restriction Mapping