European journal of medicinal chemistry, 2010-03, Vol.45 (3), p.1173-1180
2010
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles
- Ist Teil von
- European journal of medicinal chemistry, 2010-03, Vol.45 (3), p.1173-1180
- Ort / Verlag
- Kidlington: Elsevier Masson SAS
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Novel 1,5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamides ( 2a–e, 3, 3a–f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl)thiazoles ( 6a–c,7, 8, 9a–c, 10, 11) were synthesized by varying the active part (amide group) of pyrazole, characterized using IR, 1H NMR, mass spectral data and screened for their antibacterial activity against Escherichia coli (ATTC-25922), Staphylococcus aureus (ATTC-25923), Pseudomonas aeruginosa (ATTC-27853), Klebsiella pneumonia. Similarly all these compounds were screened for their antifungal activity against Aspergillus flavus (NCIM No. 524), Aspergillus fumigates (NCIM No. 902), Penicillium marneffei and Trichophyton mentagrophytes. Interestingly all the synthesized compounds exhibited good antibacterial (except 2a–c, 8, 9a) and antifungal activity (except 2a–c, 6a, 8, 9a). [Display omitted]
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0223-5234eISSN: 1768-3254DOI: 10.1016/j.ejmech.2009.12.042Titel-ID: cdi_proquest_miscellaneous_734002667
- Format
- –
- Schlagworte
- 1,5-Diaryl pyrazoles, 2-(5-(4-Chlorophenyl)-1-(4-fluorophenyl)-1 H-pyrazole-3-yl)thiazoles, 4-Piperidine amide pharmacophore, 5-(4-Chlorophenyl)-1-(4-fluorophenyl)-1 H-pyrazole-3-carboxamides, Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Antibacterial activity, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antifungal activity, Antifungal agents, Antifungal Agents - chemical synthesis, Antifungal Agents - chemistry, Antifungal Agents - pharmacology, Bacteria - drug effects, Biological and medical sciences, Chromatography, High Pressure Liquid, Fungi - drug effects, General aspects, Magnetic Resonance Spectroscopy, Medical sciences, Microbial Sensitivity Tests, Molecular Structure, Pharmacology. Drug treatments, Pyrazoles - chemical synthesis, Pyrazoles - chemistry, Pyrazoles - pharmacology, Synthesis