Bioorganic & medicinal chemistry, 2009-12, Vol.17 (24), p.8143-8148
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Interaction studies between human α-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity
- Ist Teil von
- Bioorganic & medicinal chemistry, 2009-12, Vol.17 (24), p.8143-8148
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nitric oxide-releasing α-tocopherol mimetics with LDL-protective activity were designed to maintain the tocopherol substructure necessary for its biochemical recognition by α-tocopherol transfer protein. In order to study the molecular interactions to α-TTP, theoretical binding studies by means of docking techniques and experimental binding assays, using a fluorescent probe, were performed. Furoxanyl-tocopherol-hybrid analogs 7 and 9 have the best ability to bind to α-TTP suggesting that they could be incorporated to LDL in vivo to further release nitric oxide and prevent oxidative modifications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0968-0896eISSN: 1464-3391DOI: 10.1016/j.bmc.2009.10.046Titel-ID: cdi_proquest_miscellaneous_733911249
- Format
- –
- Schlagworte
- alpha-Tocopherol, Amino Acid Substitution, Antioxidant, Antioxidants - metabolism, Biological and medical sciences, Cholesterol, LDL - chemistry, Cholesterol, LDL - metabolism, General and cellular metabolism. Vitamins, Humans, Medical sciences, Molecular Sequence Data, Nitric Oxide - biosynthesis, Nitric Oxide - metabolism, Nitric oxide donor, Nitric Oxide Donors - metabolism, Pharmacology. Drug treatments, Protein Binding, Protein Conformation, Structure-Activity Relationship, Tocopherols - metabolism, Vitamin E, Vitamin E - metabolism, α-Tocopherol transfer protein