Details

Autor(en) / Beteiligte

• Nozoe, Tadahiro
• Korenaga, Daisuke
• Ohga, Takefumi
• Futatsugi, Motonori
• Maehara, Yoshihiko

Titel

Suppression of the phytohemagglutinin response to lymphocytes is an independent prognosticator in patients with squamous cell carcinoma of the esophagus

Ist Teil von

• The Annals of thoracic surgery, 2003-07, Vol.76 (1), p.260-265

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2003

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The preoperative immunological condition of patients with malignant tumors should be considered in determining the prognosis. A lymphoblastic transformation test in which lymphocytes were stimulated with phytohemagglutinin (PHA) was performed for 155 patients with esophageal squamous cell carcinoma (SCC). Multivariate analysis demonstrated that a lower preoperative PHA response ( p = 0.028), as well as the depth of the tumor ( p = 0.011), lymph node metastasis ( p = 0.0003), lymphatic permeation ( p = 0.002), and the incidence of postoperative complication ( p = 0.016) were independent factors associated with a poor prognosis for patients with SCC of the esophagus. A suppressed PHA response is an additional significant prognosticator for SCC of the esophagus.