Details

Autor(en) / Beteiligte

• Satoh, Toyomi
• Hatae, Masayuki
• Watanabe, Yoh
• Yaegashi, Nobuo
• Ishiko, Osamu
• Kodama, Shoji
• Yamaguchi, Satoshi
• Ochiai, Kazunori
• Takano, Masashi
• Yokota, Harushige
• Kawakami, Yosuke
• Nishimura, Sadako
• Ogishima, Daiki
• Nakagawa, Shunsuke
• Kobayashi, Hiroaki
• Shiozawa, Tanri
• Nakanishi, Toru
• Kamura, Toshiharu
• Konishi, Ikuo
• Yoshikawa, Hiroyuki

Titel

Outcomes of Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer: A Proposal for Patient Selection

Ist Teil von

• Journal of clinical oncology, 2010-04, Vol.28 (10), p.1727-1732

Ort / Verlag

United States: American Society of Clinical Oncology

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective of this study was to assess clinical outcomes and fertility in patients treated conservatively for unilateral stage I invasive epithelial ovarian cancer (EOC). A multi-institutional retrospective investigation was undertaken to identify patients with unilateral stage I EOC treated with fertility-sparing surgery. Favorable histology was defined as grade 1 or grade 2 adenocarcinoma, excluding clear cell histology. A total of 211 patients (stage IA, n = 126; stage IC, n = 85) were identified from 30 institutions. Median duration of follow-up was 78 months. Five-year overall survival and recurrence-free survival were 100% [corrected] and 97.8% for stage IA and favorable histology (n = 108), 100% and 100% for stage IA and clear cell histology (n = 15), 100% and 33.3% for stage IA and grade 3 (n = 3), 96.9% and 92.1% for stage IC and favorable histology (n = 67), 93.3% and 66.0% for stage IC and clear cell histology (n = 15), and 66.7% and 66.7% for stage IC and grade 3 (n = 3). Forty-five (53.6%) of 84 patients who were nulliparous at fertility-sparing surgery and married at the time of investigation gave birth to 56 healthy children. Our data confirm that fertility-sparing surgery is a safe treatment for stage IA patients with favorable histology and suggest that stage IA patients with clear cell histology and stage IC patients with favorable histology can be candidates for fertility-sparing surgery followed by adjuvant chemotherapy.