Journal of agricultural and food chemistry, 2009-08, Vol.57 (16), p.7304-7310
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Feeding Tomato and Broccoli Powders Enriched with Bioactives Improves Bioactivity Markers in Rats
- Ist Teil von
- Journal of agricultural and food chemistry, 2009-08, Vol.57 (16), p.7304-7310
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Many studies have evaluated the cancer -preventive potential of individual bioactives from tomatoes and broccoli, but few have examined them within the context of a whole food. Male Copenhagen rats were fed diets containing 10% standard tomato powder, tomato enriched with lycopene or total carotenoids, standard broccoli floret, broccoli sprouts, or broccoli enriched with indole glucosinolates or selenium for 7 days. All broccoli diets increased the activity of colon quinone reductase (NQO1). Indole glucosinolate-enriched broccoli and selenium-enriched broccoli increased hepatic NQO1 and cytochrome P450 1A activity (P < 0.05). Standard broccoli and lycopene-enriched tomato diets down-regulated prostatic glutathione S-transferase P1 mRNA expression. Different tomato diets resulted in altered hepatic accumulation of lycopene, phytofluene, and phytoene. These results demonstrate that the bioactive content of vegetables affects both tissue content of bioactives and activity of detoxification enzymes. Enhancing bioactive content of tomatoes and broccoli may enhance efficacy in the prevention of prostate cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-8561eISSN: 1520-5118DOI: 10.1021/jf901926bTitel-ID: cdi_proquest_miscellaneous_733836466
- Format
- –
- Schlagworte
- Animals, Bioactive Constituents, bioactive properties, Biological and medical sciences, Biomarkers - analysis, Brassica - chemistry, broccoli, carotenoids, cytochrome P-450, Cytochrome P-450 Enzyme System - genetics, Cytochrome P-450 Enzyme System - metabolism, enriched foods, enzyme activity, Food industries, Fruit and vegetable industries, functional foods, Fundamental and applied biological sciences. Psychology, Gene Expression - drug effects, glucosinolates, glutathione transferase, Glutathione Transferase - genetics, Glutathione Transferase - metabolism, liver, Liver - drug effects, Liver - metabolism, lycopene, Lycopersicon esculentum - chemistry, Male, messenger RNA, metabolic detoxification, model food systems, NAD(P)H Dehydrogenase (Quinone) - genetics, NAD(P)H Dehydrogenase (Quinone) - metabolism, oxidoreductases, Plant Extracts - administration & dosage, powdered foods, prostatic neoplasms, protective effect, quinones, Random Allocation, Rats, selenium, tomatoes