Nephrology, dialysis, transplantation, 2010-01, Vol.25 (1), p.307-310
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Antibody-mediated rejection following transplantation from an HLA-identical sibling
- Ist Teil von
- Nephrology, dialysis, transplantation, 2010-01, Vol.25 (1), p.307-310
- Ort / Verlag
- Oxford: Oxford University Press
- Erscheinungsjahr
- 2010
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Putative antibody-mediated rejection (AMR) in HLA-identical sibling transplantation has rarely been reported and occurred before routine calcineurin inhibitor use. A 29-year-old male developed allograft dysfunction following an HLA-identical renal transplant from his sibling. A pretransplant panel-reactive antibody (PRA) was elevated, pre-transplant crossmatch was negative and no donor-specific antibody (DSA) was identified. Induction with alemtuzumab was followed by maintenance immunosuppression with corticosteroids, tacrolimus and mycophenolate. A biopsy for allograft dysfunction suggested AMR, but DSA could not be detected. Treatment for rejection was transiently successful. Undetectable minor histocompatibility antibodies may have contributed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0931-0509eISSN: 1460-2385DOI: 10.1093/ndt/gfp526Titel-ID: cdi_proquest_miscellaneous_733719297
- Format
- –
- Schlagworte
- acute allograft dysfunction, Adult, alemtuzumab, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Biological and medical sciences, Biopsy, Emergency and intensive care: renal failure. Dialysis management, Graft Rejection - immunology, HLA Antigens - immunology, Humans, Intensive care medicine, Kidney - pathology, Kidney Transplantation - immunology, limitations of testing, living kidney donor, Male, Medical sciences, minor histocompatibility antigens, Siblings, Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases, Surgery of the urinary system, Transplantation, Homologous