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The PAX258 gene subfamily: A comparative perspective
Developmental dynamics, 2009-12, Vol.238 (12), p.2951-2974
Goode, Debbie K.
Elgar, Greg
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Goode, Debbie K.
Elgar, Greg
Titel
The PAX258 gene subfamily: A comparative perspective
Ist Teil von
Developmental dynamics, 2009-12, Vol.238 (12), p.2951-2974
Ort / Verlag
New York: Wiley‐Liss, Inc
Erscheinungsjahr
2009
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Whole genome duplication events are thought to have substantially contributed to organismal complexity, largely via divergent transcriptional regulation. Members of the vertebrate PAX2, PAX5 and PAX8 gene subfamily derived from an ancient class of paired box genes and arose from such whole genome duplication events. These genes are critical in establishing the midbrain‐hindbrain boundary, specifying interneuron populations and for eye, ear and kidney development. Also PAX2 has adopted a unique role in pancreas development, whilst PAX5 is essential for early B‐cell differentiation. The contribution of PAX258 genes to their collective role has diverged across paralogues and the animal lineages, resulting in a complex wealth of literature. It is now timely to provide a comprehensive comparative overview of these genes and their ancient and divergent roles. We also discuss their fundamental place within gene regulatory networks and the likely influence of cis‐regulatory elements over their differential roles during early animal development. Developmental Dynamics 238:2951–2974, 2009. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1058-8388
eISSN: 1097-0177
DOI: 10.1002/dvdy.22146
Titel-ID: cdi_proquest_miscellaneous_733703533
Format
–
Schlagworte
Animals
,
choroid fissure
,
cis‐regulatory elements
,
Eye - embryology
,
Eye - growth & development
,
Eye - metabolism
,
functional redundancy
,
Humans
,
inner ear
,
kidney
,
midbrain‐hindbrain boundary
,
Models, Biological
,
Multigene Family - genetics
,
Multigene Family - physiology
,
Paired Box Transcription Factors - genetics
,
Paired Box Transcription Factors - metabolism
,
Paired Box Transcription Factors - physiology
,
PAX2
,
PAX2 Transcription Factor - genetics
,
PAX2 Transcription Factor - metabolism
,
PAX2 Transcription Factor - physiology
,
PAX5
,
PAX5 Transcription Factor - genetics
,
PAX5 Transcription Factor - metabolism
,
PAX5 Transcription Factor - physiology
,
PAX8
,
PAX8 Transcription Factor
,
Phylogeny
,
spinal cord
,
whole genome duplication
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