Details

Autor(en) / Beteiligte

• Schulte, Paul A.
• Lomax, Geoffrey

Titel

Assessment of the Scientific Basis for Genetic Testing of Railroad Workers with Carpal Tunnel Syndrome

Ist Teil von

• Journal of occupational and environmental medicine, 2003-06, Vol.45 (6), p.592-600

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• In 2000, approximately 20 railroad track workers who filed injury reports or compensation claims for carpal tunnel syndrome were tested by their employer for two genetic traits to determine the work relatedness of the condition. The testing involved deletions, variants, or mutations in the genetic coding for peripheral myelin protein (PMP22) and transthyretin (TTR). This article is an assessment of whether there is a scientific basis for such testing. A review of the scientific literature indicated that neither the scientific basis nor the population validity of the PMP22 or TTR tests for carpal tunnel syndrome were adequately established before use on railroad track workers in 2000. Although ethical and legal issues may predominate in this case, the absence of a compelling scientific basis undermines the decision to conduct the tests.