Details

Autor(en) / Beteiligte

• Anderson, Ana C
• Lord, Graham M
• Dardalhon, Valerie
• Lee, David H
• Sabatos-Peyton, Catherine A
• Glimcher, Laurie H
• Kuchroo, Vijay K

Titel

T-bet, a Th1 transcription factor regulates the expression of Tim-3

Ist Teil von

• European journal of immunology, 2010-03, Vol.40 (3), p.859-866

Ort / Verlag

Weinheim: Wiley-VCH Verlag

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• T-cell immunoglobulin, mucin domain-3 (Tim-3) is a membrane protein expressed at late stages of IFN-γ secreting CD4⁺ Th1 cell differentiation and constitutively on DC. Ligation of Tim-3 on Th1 cells terminates Th1 immune responses. In addition, Tim-3 plays a role in tolerance induction, although the mechanism by which this is accomplished has yet to be elucidated. While it is clear that Tim-3 plays an important role in the immune system, little is known regarding the molecular pathways that regulate Tim-3 expression. In the current study, we examine the role of Th1-associated transcription factors in regulating Tim-3 expression. Our experiments reveal that Tim-3 expression is regulated by the Th1-specific transcription factor T-bet. This introduces a novel paradigm into the generation of a Th1 response, whereby a transcription factor responsible for effector Th1 cell differentiation also increases the expression of a specific counter-regulatory molecule to ensure appropriate termination of pro-inflammatory Th1 immune responses.