Details

Autor(en) / Beteiligte

• Li, Yuan-Xin
• Li, Ning
• Ni, Xiao-Dong
• Li, You-Sheng
• Li, Min
• Shen, Jing
• Li, Jie-Shou

Titel

Preliminary experience with Campath 1H induction combined with low-dose monotherapy of tacrolimus in small bowel transplantation

Ist Teil von

• Chung-hua wai kʿo tsa chih, 2009-06, Vol.47 (11), p.810-813

Ort / Verlag

China

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• To report preliminary experience of the protocol of combining Campath 1H induction with low-dose monotherapy of tacrolimus and no steroid in two cases of small bowel transplantation. Campath 1H 30 mg was infused during the small bowel transplantation, and the patients were given 1 gram of methylprednisolone followed by the Campath 1H and another gram of methylprednisolone before reperfusion. Tacrolimus was infused just after the reperfusion. The tacrolimus was administered from vein first and then from gut tract, the blood tacrolimus level was controlled at 10 to 15 microg/L within the first 3 months after the operation, and reduced to 5 microg/L thereafter. The two recipients have survived more than 1 year, one received surgical closure of intestinal graft terminal stoma 13 months after the transplantation. One episode of indeterminate to mild acute rejection was verified by pathology through routine ileoscopical biopsy in each cases, and one episode of mild to moderate acute rejection occurred 8 months afte