Details

Autor(en) / Beteiligte

• Slaughter, Mark S
• Rogers, Joseph G
• Milano, Carmelo A
• Russell, Stuart D
• Conte, John V
• Feldman, David
• Sun, Benjamin
• Tatooles, Antone J
• Delgado, Reynolds M
• Long, James W
• Wozniak, Thomas C
• Ghumman, Waqas
• Farrar, David J
• Frazier, O. Howard

Titel

Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device

Ist Teil von

• The New England journal of medicine, 2009-12, Vol.361 (23), p.2241-2251

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• This comparative-effectiveness trial assessed clinical outcomes in patients with advanced heart failure who were not candidates for cardiac transplantation and who had a continuous-flow left ventricular assist device as compared with a pulsatile-flow device. The continuous-flow device resulted in better clinical outcomes, but it has not yet been approved by the Food and Drug Administration. This comparative-effectiveness trial assessed clinical outcomes in patients with advanced heart failure who had a continuous-flow left ventricular assist device as compared with a pulsatile-flow device. The continuous-flow device resulted in better clinical outcomes. Medical and electrical therapies for systolic heart failure have improved outcomes and altered the natural history of the disease. 1 – 9 However, heart failure commonly progresses and becomes refractory to current treatments. Continuous intravenous inotropic support may improve clinical status in the short term but results in a survival rate at 1 year of only 10 to 30%. 10 , 11 Cardiac transplantation is available for only a minority of patients, because of a lack of suitable donor hearts. The paucity of effective therapies for advanced heart failure led to the evaluation of mechanical circulatory-support devices as permanent therapy. To date, only two . . .