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Differential expression of specific microRNA and their targets in acute myeloid leukemia
American journal of hematology, 2010-05, Vol.85 (5), p.331-339
Cammarata, Giuseppe
Augugliaro, Luigi
Salemi, Domenico
Agueli, Cecilia
Rosa, Maria La
Dagnino, Lea
Civiletto, Gabriele
Messana, Francesca
Marfia, Anna
Bica, Maria Grazia
Cascio, Lucia
Floridia, Pietro Michele
Mineo, Angelo M.
Russo, Mario
Fabbiano, Francesco
Santoro, Alessandra
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Cammarata, Giuseppe
Augugliaro, Luigi
Salemi, Domenico
Agueli, Cecilia
Rosa, Maria La
Dagnino, Lea
Civiletto, Gabriele
Messana, Francesca
Marfia, Anna
Bica, Maria Grazia
Cascio, Lucia
Floridia, Pietro Michele
Mineo, Angelo M.
Russo, Mario
Fabbiano, Francesco
Santoro, Alessandra
Titel
Differential expression of specific microRNA and their targets in acute myeloid leukemia
Ist Teil von
American journal of hematology, 2010-05, Vol.85 (5), p.331-339
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
MEDLINE
Beschreibungen/Notizen
Acute myeloid leukemia (AML) the most common acute leukemia in adults is characterized by various cytogenetic and molecular abnormalities. However, the genetic etiology of the disease is not yet fully understood. MicroRNAs (miRNA) are small noncoding RNAs which regulate the expression of target mRNAs both at transcriptional and translational level. In recent years, miRNAs have been identified as a novel mechanism in gene regulation, which show variable expression during myeloid differentiation. We studied miRNA expression of leukemic blasts of 29 cases of newly diagnosed and genetically defined AML using quantitative reverse transcription polymerase chain reaction (RT‐PCR) for 365 human miRNA. We showed that miRNA expression profiling reveals distinctive miRNA signatures that correlate with cytogenetic and molecular subtypes of AML. Specific miRNAs with consolidated role on cell proliferation and differentiation such as miR‐155, miR‐221, let‐7, miR‐126 and miR‐196b appear to be associated with particular subtypes. We observed a significant differentially expressed miRNA profile that characterizes two subgroups of AML with different mechanism of leukemogenesis: core binding factor (CBF) and cytogenetically normal AML with mutations in the genes of NPM1 and FLT3‐ITD. We demonstrated, for the first time, the inverse correlation of expression levels between miRNA and their targets in specific AML genetic groups. We suggest that miRNA deregulation may act as complementary hit in the multisteps mechanism of leukemogenesis offering new therapeutic strategies. Am. J. Hematol. 2010. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0361-8609
eISSN: 1096-8652
DOI: 10.1002/ajh.21667
Titel-ID: cdi_proquest_miscellaneous_733557989
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Case-Control Studies
,
Cell Differentiation - genetics
,
Cell Proliferation
,
Core Binding Factors - physiology
,
Down-Regulation
,
Female
,
fms-Like Tyrosine Kinase 3 - genetics
,
Gene Expression Profiling
,
Gene Expression Regulation, Neoplastic
,
Granulocyte Precursor Cells - metabolism
,
Hematologic and hematopoietic diseases
,
Humans
,
Leukemia, Myeloid, Acute - classification
,
Leukemia, Myeloid, Acute - genetics
,
Leukemia, Myeloid, Acute - physiopathology
,
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
,
Male
,
Medical sciences
,
MicroRNAs - genetics
,
MicroRNAs - metabolism
,
Middle Aged
,
Mutation
,
Nuclear Proteins - genetics
,
Reverse Transcriptase Polymerase Chain Reaction
,
Up-Regulation
,
Young Adult
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