Details

Autor(en) / Beteiligte

• Silverman, Gregg J
• Grönwall, Caroline
• Vas, Jaya
• Chen, Yifang

Titel

Natural autoantibodies to apoptotic cell membranes regulate fundamental innate immune functions and suppress inflammation

Ist Teil von

• Discovery medicine, 2009-10, Vol.8 (42), p.151-156

Ort / Verlag

United States

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• The evolution of the immune system has provided a multilevel system that interconnects the innate and adaptive immune systems to serve at least three central purposes: the defense from microbial pathogens, the capacity for discrimination of self- from non-self necessary for the prevention of autoimmune disease, and essential effector roles in wound repair and tissue remodeling. In recent studies, we have elucidated an unsuspected role for a class of naturally occurring autoreactive antibodies from the most primitive tier of B lymphocytes, which regulates fundamental functions of the innate immune system. Our findings also throw light onto long unresolved mysteries regarding the origins of the earliest waves of B lymphocyte development.