Details

Autor(en) / Beteiligte

• Ferreira, Sabrina B.
• de Carvalho da Silva, Fernando
• Bezerra, Flávio A. F. M.
• Lourenço, Maria C. S.
• Kaiser, Carlos R.
• Pinto, Angelo C.
• Ferreira, Vitor F.

Titel

Synthesis of α- and β-Pyran Naphthoquinones as a New Class of Antitubercular Agents

Ist Teil von

• Archiv der Pharmazie (Weinheim), 2010-02, Vol.343 (2), p.81-90

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• A series of α‐ and β‐pyran naphthoquinones (lapachones) have been synthesized and evaluated for their in‐vitro antibacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using the Alamar‐Blue susceptibility test; the activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The synthetic methodology consisted of the formation of methylene and aryl o‐quinone methides (o‐QMs) generated by Knoevenagel condensation of 2‐hydroxy‐1,4‐naphthoquinone with formaldehyde and arylaldehydes. These o‐QMs then undergo facile hetero Diels–Alder reactions with dienophiles in aqueous ethanol media. Some naphthoquinones exhibited inhibition with MIC values of 1.25 μg/mL, similar to that of pharmaceutical concentrations currently used in tuberculosis treatment. These results justify further research into the value of these quinones as part of an original treatment for tuberculosis.