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Dual Tracer 11C-Choline and FDG-PET in the Diagnosis of Biochemical Prostate Cancer Relapse After Radical Treatment
Ist Teil von
Molecular imaging and biology, 2010-04, Vol.12 (2), p.210-217
Ort / Verlag
New York: Springer-Verlag
Erscheinungsjahr
2010
Link zum Volltext
Quelle
SpringerLink (Online service)
Beschreibungen/Notizen
Purpose
The purpose of this study was to evaluate a dual tracer 2-deoxy-2-[F-18]fluoro-
d
-glucose (FDG) and
11
C-choline positron emission tomography (PET) protocol in the detection of biochemical prostate cancer relapse.
Procedures
Seventy-three patients (median Prostate Specific Antigen (PSA) Test value 2.7 ng/ml (1.1–5.4)) after radical treatment. PET scans were performed by means of a ECAT-Exact HR+ in the first 18 patients and in a PET/computed tomography Biograph II in the remaining 55 patients.
Results
The sensitivity of
11
C-choline and FDG was 60.6% and 31%. In PSA levels over 1.9 ng/ml, sensitivity increased to 80% and 40%, respectively. In the group receiving adjuvant hormone therapy, the diagnostic yields were 71.2% and 43%, respectively. While
11
C-choline-PET could not differentiate well and poorly differentiated Gleason score patients, FDG-PET results were almost significant (
p
= 0.058).
Conclusions
A PSA value higher than 1.9 ng/ml determines a significant increase in the diagnostic yield. Adjuvant hormonotherapy has no influence on the PET results. FDG has a better correlation with the Gleason score than
11
C-choline.