Details

Autor(en) / Beteiligte

• Meiland, Ruby
• Geerlings, Suzanne E
• Stolk, Ronald P
• Hoepelman, Andy I
• Peeters, Petra H
• Coenjaerts, Frank E
• Grobbee, Diederik E

Titel

Escherichia coli bacteriuria in female adults is associated with the development of hypertension

Ist Teil von

• International journal of infectious diseases, 2010-04, Vol.14 (4), p.e304-e307

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objective To investigate whether Escherichia coli bacteriuria is associated with the development of hypertension during a long-term follow-up. Methods A prospective cohort study was performed among the participants of two population-based studies. Between 1974 and 1986 all women aged 39 to 68 years old, who lived in Utrecht, the Netherlands, were invited to participate in a breast cancer screening program. The participants completed a questionnaire, underwent a medical examination, and collected a morning urine sample that remained stored. From 1993 to 1997 another population-based study was performed. We performed a full cohort analysis for 444 women who participated in both studies. E. coli bacteriuria was diagnosed by a real-time PCR. Hypertension was defined as the use of antihypertensive medication and/or a measured systolic blood pressure of at least 160 mmHg or a diastolic blood pressure of 95 mmHg or higher. The mean follow-up was 11.5 ± 1.7 years. Results Forty women (9%) had E. coli bacteriuria at baseline. Women who had bacteriuria at baseline had a mean blood pressure at study endpoint of 133 ± 20 mmHg systolic and 78 ± 11 mmHg diastolic, and women without bacteriuria had values of 129 ± 20 and 78 ± 11 mmHg, respectively ( p -values for difference 0.33 and 0.88). Although E. coli bacteriuria was not associated with the blood pressure as a continuous variable, it was associated with the development of hypertension during follow-up (OR 2.8, 95% CI 1.4–5.5). Conclusion E. coli bacteriuria may increase the risk of future hypertension.