Chung-hua fu chʿan kʿo tsa chih, 2009-03, Vol.44 (3), p.183-187
2009
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- Autor(en) / Beteiligte
- Titel
- Association of the calpain-10 gene polymorphism with glucose metabolism disorder in pregnant women
- Ist Teil von
- Chung-hua fu chʿan kʿo tsa chih, 2009-03, Vol.44 (3), p.183-187
- Ort / Verlag
- China
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To study three single nucleotide polymorphisms (SNP), SNP-43, -19 and -63 of calpain-10 (CAPN10) gene in pregnant women with glucose metabolism disorders and their relationship with the risk of these disorders. Totally, 270 pregnant women including 156 with an abnormal oral glucose tolerance test (study group) and 114 healthy controls were selected among those delivered at the Department of Obstetrics and Gynecology, Peking University First Hospital from Jan. 2005 to Dec. 2006. The SNP of CAPN10 gene at positions 43, 19, and 63 were analyzed by primer-introduced restriction analysis-polymerase chain reaction (PIRA-PCR). (1) The frequencies CAPN10 SNP-19 2R/2R genotype (26.9%, 42/156) and 2R allele (48.9%, 152/312) were higher than those in controls (12.3%, 14/114 and 36.8%, 84/228, respectively; P=0.012, 0.006). (2) Stratified analysis according to family history of diabetes mellitus showed the proportion of the CAPN10 SNP-19 2R/2R+2R/3R genotypes (83%, 47/57) in the study group were significantly higher than
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0529-567XTitel-ID: cdi_proquest_miscellaneous_733363603
- Format
- –
- Schlagworte
- Adult, Alleles, Blood Glucose - metabolism, Calpain - genetics, Case-Control Studies, Diabetes, Gestational - genetics, DNA Primers, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Glucose Metabolism Disorders - genetics, Haplotypes, Humans, Polymerase Chain Reaction - methods, Polymorphism, Single Nucleotide - genetics, Pregnancy, Pregnancy Complications - genetics, Risk Factors