Journal of agricultural and food chemistry, 2010-06, Vol.58 (12), p.7172-7179
2010
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Details
- Autor(en) / Beteiligte
- Titel
- In Vitro and in Vivo Effects of Apple Peel Polyphenols against Helicobacter pylori
- Ist Teil von
- Journal of agricultural and food chemistry, 2010-06, Vol.58 (12), p.7172-7179
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The inhibitory effects of a standarized apple peel polyphenol-rich extract (APPE) against Helicobacter pylori infection and vacuolating bacterial toxin (VacA) induced vacuolation were investigated. Apple peel polyphenols significantly prevented vacuolation in HeLa cells with an IC50 value of 390 μg of gallic acid equivalents (GAE)/mL. APPE also displayed an in vitro antiadhesive effect against H. pylori. A significant inhibition was observed with a 20−60% reduction of H. pylori attachment at concentrations between 0.250 and 5 mg of GAE/mL. In a short-term infection model (C57BL6/J mice), two levels of APPE doses (150 and 300 mg/kg/day) showed an inhibitory effect on H. pylori attachment. Orally administered apple peel polyphenols also showed an anti-inflammatory effect on H. pylori-associated gastritis, lowering malondialdehyde levels and gastritis scores.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-8561eISSN: 1520-5118DOI: 10.1021/jf100274gTitel-ID: cdi_proquest_miscellaneous_733347193
- Format
- –
- Schlagworte
- Administration, Oral, animal models, Animals, anti-inflammatory activity, antibacterial properties, apples, bacterial adhesion, bacterial infections, bacterial toxins, Bioactive Constituents, Biological and medical sciences, cell lines, Chlorogenic Acid - administration & dosage, Chlorogenic Acid - pharmacology, dose response, enteropathogens, Flavonoids - administration & dosage, Flavonoids - pharmacology, Food industries, Fruit and vegetable industries, Fundamental and applied biological sciences. Psychology, gastritis, Gastritis - drug therapy, Gastritis - microbiology, HeLa Cells, Helicobacter Infections - drug therapy, Helicobacter Infections - microbiology, Helicobacter pylori, Helicobacter pylori - drug effects, Helicobacter pylori - genetics, Helicobacter pylori - isolation & purification, Helicobacter pylori - physiology, Humans, in vitro studies, in vivo studies, malondialdehyde, Malus - chemistry, Mice, Mice, Inbred C57BL, peels, phytochemicals, polyphenols, Tannins - administration & dosage, Tannins - pharmacology, vacuoles