Details

Autor(en) / Beteiligte

• J.A. Sanz-Herrera
• J.M. García-Aznar
• M. Doblaré

Titel

A mathematical approach to bone tissue engineering

Ist Teil von

• Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences, 2009-05, Vol.367 (1895), p.2055-2078

Ort / Verlag

London: The Royal Society

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Tissue engineering is becoming consolidated in the biomedical field as one of the most promising strategies in tissue repair and regenerative medicine. Within this discipline, bone tissue engineering involves the use of cell-loaded porous biomaterials, i.e. bioscaffolds, to promote bone tissue regeneration in bone defects or diseases such as osteoporosis, although it has not yet been incorporated into daily clinical practice. The overall success of a particular bone tissue engineering application depends strongly on scaffold design parameters, which do away with long and expensive clinical protocols. Computer simulation is a useful tool that may reduce animal experiments and help to identify optimal patient-specific designs after concise model validation. In this paper, we present a novel mathematical approach to bone regeneration within scaffolds, based on a multiscale framework. Results are presented over an actual scaffold microstructure, showing the potential of computer simulation, and how it can aid in the task of making bone tissue engineering a reality in clinical practice.