Details

Autor(en) / Beteiligte

• Abu-Hashem, A.A.
• Gouda, M.A.
• Badria, F.A.

Titel

Synthesis of some new pyrimido[2′,1′:2,3]thiazolo[4,5- b]quinoxaline derivatives as anti-inflammatory and analgesic agents

Ist Teil von

• European journal of medicinal chemistry, 2010-05, Vol.45 (5), p.1976-1981

Ort / Verlag

Kidlington: Elsevier Masson SAS

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Treatment of 6-aminothiouracil ( 1) with 2,3-dichloroquinoxaline ( 2) in ethanol/TEA afforded 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3 H)-one ( 3), which was refluxed in DMF to give 2-aminopyrimido[2′,1′:2,3]thiazolo[4,5- b]quinoxaline-4-one ( 4). Compound 4 was utilized as a key intermediate for the synthesis of a new pyrimido[2′,1′:2,3]thiazolo[4,5- b]quinoxaline derivatives 5– 14 via the reaction with 2-chlorobenzaldehyde, 2-chlorocyclohex-1-enecarbaldehyde, 2-chlorobenzoic acid, 2,4-dichlorobenzoic acid, 5-chloro-3-methyl-1-phenyl-1 H-pyrazole-4-carbaldehyde, 2-chloro-4,6-dimethylnicotinonitrile, α,β-unsaturated ketones and isonicotinaldehyde, respectively. The chemical structures of the newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. These compounds were also screened for their analgesic and anti-inflammatory activities. Some of these compounds ( 3, 4, 9, 10 and 12– 14) exhibited promising activities. [Display omitted]