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Influences of dibutyryl cyclic adenosine monophosphate and forskolin on human sperm motility in vitro
Ist Teil von
Asian journal of andrology, 2003-06, Vol.5 (2), p.113-115
Ort / Verlag
Oxford: blackwell
Erscheinungsjahr
2003
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Aim: To study the influences of dibutyryl cyclic adenosine monophosphate (dbcAMP) and forskolin on human sperm motility in vitro. Methods: Semen samples, aseptically obtained by masturbation and prepared by swim-up technique from 20 fertile men, were incubated with different concenlrations of dbcAMP and forskolin at 37℃. Measurements were carried out after l0 min, 20 min, 30 min and 60 min incubation. Motility parameters were estimated by using an automatic analyzing system. Results: Treatment with dbcAMP or forskolin resulted in a significant increase in sperm motility and progressive motility. The larger the concenlrations of dbcAMP or forskolin,the greater the effect appeared. The straight linear velocity and curvilinear velocity were not affected by both agents.Conclusion: dbcAMP and forskolin increase the motility and progressive motility of human sperm in vitro. ( Asian J Androl 2003 Jun; 5: 113-115)