Details

Autor(en) / Beteiligte

• Wing, K.D
• Slawecki, R.A
• Carlson, G.R

Titel

RH 5849, a nonsteroidal ecdysone agonist: effects on larval Lepidoptera

Ist Teil von

• Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4864), p.470-472

Ort / Verlag

Washington, DC: The American Association for the Advancement of Science

Erscheinungsjahr

1988

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The ecdysone agonist RH 5849 (1,2-dibenzoyl-1-tert-butylhydrazine) causes the premature initiation of molting at all stages of larval development of the tobacco hornworm, Manduca sexta. This phenomone occurs without an increase in the endogenous ecdysone (20-hydroxyecdysone) titers. RH 5849 likewise provokes the initiation of molting in larval abdomens in the absence of a source of endogenous hormone. Although substantially less active than 20-hydroxyecdysone in vitro, RH 5849 was 30 to greater than 670 times as active as the authentic molting hormone in bioassays with isolated larval abdomens or intact hornworms. This reversal in potency can be attributed to the superior transport properties and metabolic stability of RH 5849 relative to 20-hydroxyecdysone. Thus RH 5849 and its analogs are relatively persistent ecdysone agonists that halt feeding in larval lepidoptera by forcing an ultimately lethal, developmentally premature molt