Details

Autor(en) / Beteiligte

• Yun, Sang Young
• Hansen, Eric C
• Volchkov, Ivan
• Cho, Eun Jin
• Lo, Wai Yip
• Lee, Daesung

Titel

Total Synthesis of (-)-Dactylolide

Ist Teil von

• Angewandte Chemie (International ed.), 2010-06, Vol.49 (25), p.4261-4263

Ort / Verlag

Weinheim: Wiley-VCH Verlag

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Multiple metals in action: Relying on the prowess of various metal‐catalyzed CO and CC bond‐forming reactions, a concise asymmetric total synthesis of (−)‐dactylolide has been achieved (see scheme). The formation of a Z‐trisubstituted vinylboronate through an Alder–ene reaction and subsequent rhenium‐mediated regioselective transposition of an allylic alcohol are the key features of this convergent synthesis.