Details

Autor(en) / Beteiligte

• MA, Linlin
• LIN, Shouqing
• CHEN, Rong
• ZHANG, Ying
• CHEN, Fengling
• WANG, Xiuli

Titel

Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Ist Teil von

• Australian & New Zealand journal of obstetrics & gynaecology, 2010-04, Vol.50 (2), p.189-193

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Objectives:  To assess therapeutic effect of an extract of Vitex agnus castus (VAC, BNO 1095) in premenstrual syndrome (PMS) in Chinese women. Design:  It was a prospective, randomised, double‐blind, placebo‐controlled study carried out in China. Eligible patients were treated with VAC extract or placebo for three cycles. Symptoms were documented with PMS diary (PMSD), a daily rating scale with 17 items. Main efficacy variable was the reduction percentage of 17 symptom score documented in PMSD during the luteal phase of the third treatment cycle. Results:  A total of 67 patients were enrolled and randomly assigned to VAC group or placebo group. Of these, 64 patients completed the study (31 vs. 33). All the 17 symptoms showed a significantly greater improvement with VAC than placebo (P < 0.05) except lower abdominal cramping (P > 0.05). Conclusion:  Vitex agnus castus is more effective than placebo in the treatment of moderate‐to‐severe PMS in Chinese women, especially in symptoms of negative effect and insomnia.