Details

Autor(en) / Beteiligte

• Cao, Y.Z. (The Pennsylvania State University, University Park, PA)
• Maddox, J.F
• Mastro, A.M
• Scholz, R.W
• Hildenbrandt, G
• Channa Reddy, C

Titel

Selenium deficiency alters the lipoxygenase pathway and mitogenic response in bovine lymphocytes

Ist Teil von

• The Journal of nutrition, 1992-11, Vol.122 (11), p.2121-2127

Ort / Verlag

Bethesda, MD: American Society for Nutritional Sciences

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• We investigated the effect of altered selenium (Se) nutrition on arachidonic acid oxidation in immune cells. Experiments were conducted with peripheral blood lymphocytes obtained from dairy cattle fed diets either supplemented with or deficient in Se. The results indicate that the concanavalin A-stimulated lymphocyte proliferation was significantly lower in Se-deficient cows. When stimulated by calcium ionophore A23187, the lymphocytes derived from Se-deficient cows produced significantly less 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) than those obtained from Se-supplemented cows. When included in cell cultures from animals fed +Se diets, 5-HETE and LTB4 elicited a partial reversal of the inhibition of lymphocyte proliferation by either hydrocortisone or nordihydroguaiaretic acid. Based on this information, we postulate that dietary Se status, which in turn determines tissue Se concentration, plays an important role in the regulation of arachidonate metabolism by way of the 5-lipoxygenase pathway. This may be one of the biochemical mechanisms underlying the inhibition of lymphocyte proliferation and the decrease in resistance to infectious diseases observed in Se-deficient animals