Details

Autor(en) / Beteiligte

• Qiu, Rong-Xin
• Li, Chun-Min
• Ye, Lin
• Dong, Jian-De
• Zhang, Ai-Ying
• Gu, Yong-Quan
• Feng, Zeng-Guo

Titel

Electrospinning of synthesized triblock copolymers of ε-caprolactone and L-lactide for the application of vascular tissue engineering

Ist Teil von

• Biomedical materials (Bristol), 2009-08, Vol.4 (4), p.044105-044105

Ort / Verlag

England: IOP Publishing

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Biodegradable triblock copolymers of epsilon-caprolactone and L-lactide with varying compositions and molecular weights have been synthesized. They were then used to fabricate compliant small-diameter tissue engineered vascular scaffolds by using an electrospinning technique. The in vitro and in vivo degradation of the ultrafine fabrics was monitored to be faster than their counterpart cast films. A favorable interaction between the scaffolds and the mouse fibroblast L929 cells was demonstrated via MTT assay. A confluent, adherent monolayer of canine mesenchymal stem cells was observed in the tubular scaffold lumen after culture in a bioreactor for 3 days. The scaffold mechanical strength was strong enough to be transplanted into the canine carotid artery.