Details

Autor(en) / Beteiligte

• Wheatley, Keith
• Ives, Natalie
• Gray, Richard
• Kalra, Philip A
• Moss, Jonathan G
• Baigent, Colin
• Carr, Susan
• Chalmers, Nicholas
• Eadington, David
• Hamilton, George
• Lipkin, Graham
• Nicholson, Anthony
• Scoble, John

Titel

Revascularization versus Medical Therapy for Renal-Artery Stenosis

Ist Teil von

• The New England journal of medicine, 2009-11, Vol.361 (20), p.1953-1962

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• In a clinical trial, 806 patients with renovascular disease were randomly assigned either to undergo percutaneous revascularization with medical therapy or to receive medical therapy alone. At a median follow-up of 34 months, the rate of decline in renal function (the primary end point) did not differ significantly between the two groups. Serious complications of revascularization occurred in 23 patients. Patients with renovascular disease were randomly assigned either to undergo percutaneous revascularization with medical therapy or to receive medical therapy alone. At 34 months, the rate of decline in renal function did not differ significantly between the two groups. Atherosclerotic renovascular disease is a common condition with a rate of death of about 16% per year, largely from associated cardiovascular disease. 1 – 3 Stenosis of the renal artery is associated with both hypertension and chronic kidney disease, although it is not clear whether these associations are causal. 4 Treatment has traditionally focused on correcting renal-artery stenosis, with endovascular revascularization having gradually replaced open surgical techniques. Three small, randomized, controlled trials showed no significant benefits of angioplasty over medical therapy, 5 – 7 but these studies were underpowered, even when their results were combined, 8 to detect possible moderate but clinically worthwhile improvements in renal . . .