Details

Autor(en) / Beteiligte

• Carlo, Waldemar A
• Finer, Neil N
• Walsh, Michele C
• Rich, Wade
• Gantz, Marie G
• Laptook, Abbot R
• Yoder, Bradley A
• Faix, Roger G
• Das, Abhik
• Poole, W Kenneth
• Schibler, Kurt
• Newman, Nancy S
• Ambalavanan, Namasivayam
• Frantz, 3rd, Ivan D
• Piazza, Anthony J
• Sánchez, Pablo J
• Morris, Brenda H
• Laroia, Nirupama
• Phelps, Dale L
• Poindexter, Brenda B
• Cotten, C Michael
• Van Meurs, Krisa P
• Duara, Shahnaz
• Narendran, Vivek
• Sood, Beena G
• O'Shea, T Michael
• Bell, Edward F
• Ehrenkranz, Richard A
• Watterberg, Kristi L
• Higgins, Rosemary D

Titel

Target Ranges of Oxygen Saturation in Extremely Preterm Infants

Ist Teil von

• The New England journal of medicine, 2010-05, Vol.362 (21), p.1959-1969

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2010

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This large randomized trial with a 2-by-2 factorial design compared a lower target range of oxygen saturation (85 to 89%) with a higher target range (91 to 95%) in extremely preterm infants. The lower target range did not significantly decrease the combined outcome of severe retinopathy or death, but it resulted in an increase in mortality and a substantial decrease in severe retinopathy among survivors. A lower target range of oxygen saturation did not significantly decrease the combined outcome of severe retinopathy or death, but it resulted in an increase in mortality and a substantial decrease in severe retinopathy among survivors. Retinopathy of prematurity is an important cause of blindness and other visual disabilities in preterm infants. The incidence of retinopathy of prematurity was increased with exposure to unrestricted oxygen supplementation in preterm infants in randomized, controlled trials performed in the 1950s. 1 In the 1960s, this increase resulted in the practice of restricting the fraction of inspired oxygen (FIO 2 ) to no more than 0.50, which was estimated to result in an excess of 16 deaths per case of blindness prevented. 2 More recent data suggest that levels of oxygen saturation previously thought to be at the upper end of the . . .