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Familial Graves' Disease Associated with Type 1 Diabetes
Ist Teil von
Internal Medicine, 2009, Vol.48(9), pp.701-704
Ort / Verlag
Japan: The Japanese Society of Internal Medicine
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
A 59-year-old woman was diagnosed as having Graves' disease and type 1 diabetes. DNA molecular HLA typing detected DRB1*0405 and DQB1*0401, as well as the haplotypes of DRB1*0901-DQB1*0303. We also performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to identify allele variations of other loci. The patient's son also manifested Graves' disease and type 1 diabetes, with both cases having strikingly homologous clinical features. Familial clustering of Graves' disease and type 1 diabetes, and their tendency to occur together along with a similar clinical course suggest that their etiology may involve shared genetic factors.