Details

Autor(en) / Beteiligte

• Shukla, Praphulla C., PhD
• Singh, Krishna K., PhD
• Yanagawa, Bobby, MD PhD
• Teoh, Hwee, PhD
• Verma, Subodh, MD PhD

Titel

DNA damage repair and cardiovascular diseases

Ist Teil von

• Canadian journal of cardiology, 2010-03, Vol.26, p.13A-16A

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• DNA turnover through damage and repair is a normal homeostatic process in viable cells. DNA damage induces sequential responses to either repair the damage or activate a programmed cell death process. Defects in this critical response to DNA damage underpin a wide array of human pathologies that include cancer predisposition, immune dysfunction, radiosensitivity and neurodegeneration. Recent experimental and clinical studies have suggested that oxidative stress leading to catastrophic DNA damage is enhanced in failing hearts as well as other cardiovascular diseases. Accordingly, targeting the genotoxic effects of oxidative stress may prove to be a novel avenue in the development of rational therapies for cardiovascular diseases. A platform introduction to DNA damage and repair is provided, relevant findings related to cardiovascular diseases associated with DNA damage or defects in DNA repair/response are integrated, and insights into the future directions of this exciting field are offered.