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Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients
Ist Teil von
The American journal of psychiatry, 1992-11, Vol.149 (11), p.1543-1548
Ort / Verlag
Washington, DC: American Psychiatric Publishing
Erscheinungsjahr
1992
Quelle
MEDLINE
Beschreibungen/Notizen
OBJECTIVE: The authors examined the relationship between negative
symptoms and premorbid variables in drug-free schizophrenic patients.
METHOD: The authors studied 63 clinically stable male schizophrenic
inpatients who were not receiving any psychoactive medication. The patients
were classified as having negative, positive, or mixed symptoms, and their
premorbid functioning during childhood, early adolescence, and late
adolescence was assessed by using the Premorbid Adjustment Scale.
Correlational analyses were applied to the classification and developmental
models. RESULTS: Patients with negative symptoms had significantly lower
levels of premorbid functioning during late adolescence and significantly
greater premorbid deterioration between childhood and early adolescence.
Correlational analysis revealed significant positive relationships between
premorbid variables and negative symptoms. CONCLUSIONS: The data suggest
that a deterioration in social and intellectual functioning between
childhood and adolescence is associated with the development of a negative
symptom syndrome in schizophrenia. The premorbid deterioration appears to
be an early prodrome of the disorder. Whether this residual negative
symptom syndrome is in some way related to the deficit syndrome of
schizophrenia awaits a prospective study.