Details

Autor(en) / Beteiligte

• Fuller, CJ
• Faulkner, H
• Bendich, A
• Parker, RS
• Roe, DA

Titel

Effect of β -carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men

Ist Teil von

• The American journal of clinical nutrition, 1992-10, Vol.56 (4), p.684-690

Ort / Verlag

Bethesda, MD: Elsevier Inc

Erscheinungsjahr

1992

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The aim of this study was to examine whether β-carotene protects against the immunosuppression seen with long-wave ultraviolet-light (UV-A) exposure. Free-living, healthy men, aged 19–39 y received 30 mg β-carotene/d or a placebo while on a single-menu, low-carotenoid diet. After 28 d all subjects received 12 exposures to a UV-A/B light source over a 16-d period. The total UV-A dose received ranged from 15.9 to 19.3 J/cm2. The total shorter-wave ultraviolet-light (UV-B) dose varied from 1.59 to 1.96 J/cm2. Follow-up continued for 21 d. Carotenoid assays and delayed-type hypersensitivity (DTH) tests were performed at baseline, pre-UV, post-UV, and after followup. The DTH-test responses were significantly suppressed in the placebo group after UV treatments. The suppression was inversely related to plasma β-carotene concentrations in this group. There was no significant suppression of DTH test responses in theβ-carotene group. It is concluded that β-carotene protects against photosuppression of immune function.