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Collapsing glomerulopathy
Seminars in nephrology, 2003-03, Vol.23 (2), p.209-218
Schwimmer, Joshua A.
Markowitz, Glen S.
Valeri, Anthony
Appel, Gerald B.
2003
Details
Autor(en) / Beteiligte
Schwimmer, Joshua A.
Markowitz, Glen S.
Valeri, Anthony
Appel, Gerald B.
Titel
Collapsing glomerulopathy
Ist Teil von
Seminars in nephrology, 2003-03, Vol.23 (2), p.209-218
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2003
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Collapsing glomerulopathy is a morphologic variant of focal segmental glomerulosclerosis (FSGS) characterized by segmental and global collapse of the glomerular capillaries, marked hypertrophy and hyperplasia of podocytes, and severe tubulointerstitial disease. The cause of this disorder is unknown, but nearly identical pathologic findings are present in idiopathic collapsing glomerulopathy and human immunodeficiency virus (HIV)-associated nephropathy, and collapsing glomerulopathy has been associated with parvovirus B19 infection and treatment with pamidronate. The pathogenesis of collapsing glomerulopathy involves visceral epithelial cell injury leading to cell cycle dysregulation and a proliferative phenotype. Clinically, collapsing glomerulopathy is characterized by black racial predominance, a high incidence of nephrotic syndrome, and rapidly progressive renal failure. Collapsing glomerulopathy also may recur after renal transplantation or present de novo, often leading to loss of the allograft. The optimal treatment for collapsing glomerulopathy is unknown. Treatments may include steroids or cyclosporine in addition to aggressive blood pressure control, angiotensin converting enzyme inhibitors and/or angiotensin II receptor blockers, and lipid lowering agents. The role of other immunosuppressive agents such as mycophenolate mofetil in the treatment of collapsing FSGS remains to be defined. Prospective clinical trials are needed to define optimal therapy of this aggressive form of FSGS. © 2003 Elsevier Inc. All rights reserved.
Sprache
Englisch
Identifikatoren
ISSN: 0270-9295
eISSN: 1558-4488
DOI: 10.1053/snep.2003.50019
Titel-ID: cdi_proquest_miscellaneous_73210410
Format
–
Schlagworte
Capillaries - pathology
,
Disease Progression
,
Glomerulosclerosis, Focal Segmental - epidemiology
,
Glomerulosclerosis, Focal Segmental - pathology
,
Glomerulosclerosis, Focal Segmental - therapy
,
Humans
,
Incidence
,
Kidney Glomerulus - blood supply
,
Kidney Glomerulus - pathology
,
Nephrotic Syndrome - etiology
,
Nephrotic Syndrome - pathology
,
Nephrotic Syndrome - therapy
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