Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Association between the Pl A platelet glycoprotein GPIIIa polymorphism and extent of coronary artery disease
Ist Teil von
International journal of cardiology, 2003-04, Vol.88 (2), p.229-237
Ort / Verlag
Netherlands: Elsevier Ireland Ltd
Erscheinungsjahr
2003
Quelle
ScienceDirect
Beschreibungen/Notizen
Background: The
Pl
A2
allele of the gene encoding for GPIIIa subunit of the platelet membrane receptor glycoprotein (GP) IIb/IIIa has been suggested as a significant risk factor for thrombotic complications of coronary artery disease (CAD). The aim of the current investigation was to investigate the association between
Pl
A GPIIIa
polymorphism and the extent of angiographically confirmed CAD in patients from the north region of Poland.
Methods: The study was performed in 397 male Caucasian patients. All subjects had significant coronary artery stenosis confirmed by elective coronary angiography. Screening for the
Pl
A GPIIIa
genotypes was performed by polymerase chain reaction of genomic DNA, followed by
NciI digestion and agarose gel electrophoresis.
Results: The genotype distribution of the
Pl
A GPIIIa
polymorphism in our study group was
Pl
A1/A1
—75%,
Pl
A1/A2
—24% and
Pl
A2/A2
—1% with
Pl
A1
and
Pl
A2
allele frequencies of 0.87 and 0.13, respectively. The prevalence of the homozygous
Pl
A1/A1
genotype among subjects with multiple-vessel CAD (two or three vessels with at least 50% stenosis) was significantly higher than in patients with single-vessel disease; the odds ratio of
Pl
A2/A2
or
Pl
A1/A2
patients for having multiple-vessel CAD was 0.46 (95% CI 0.27–0.77,
P<0.01). The mean CAD score for
Pl
A1/A1
patients was significantly higher in comparison to
Pl
A2/A2
and
Pl
A1/A2
patients (7.58±2.20 and 6.98±2.37, respectively,
P<0.05).
Conclusions: Our results suggest, that the
Pl
A1/A1
genotype of
Pl
A GPIIIa
polymorphism is associated with more severe CAD in male Caucasian patients from the north region of Poland.