FEBS letters, 1992-09, Vol.309 (2), p.199-202
1992
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Details
- Autor(en) / Beteiligte
- Titel
- The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease
- Ist Teil von
- FEBS letters, 1992-09, Vol.309 (2), p.199-202
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1992
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The paired helical filament, which comprises the major fibrous element of the neurofibrillary tangle in Alzheimer's disease, contains abnormally phosphorylated microtubule-associated protein tau as its principal constituent. The repeat region of tau protein, which represents the microtubule binding domain, forms the core of the filament. Here we show that an expressed fragment of tau protein spanning the repeat region can assemble in vitro into filaments like those found in Alzheimer's disease
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(92)81094-3Titel-ID: cdi_proquest_miscellaneous_73150165
- Format
- –
- Schlagworte
- Alzheimer Disease - metabolism, Alzheimer's desease, Alzheimer's disease, Amino Acid Sequence, Analytical, structural and metabolic biochemistry, assembly, binding, Binding and carrier proteins, Biological and medical sciences, Cloning, Molecular, Fundamental and applied biological sciences. Psychology, Humans, Macromolecular Substances, Microscopy, Electron, Microtubule-associated protein tau, microtubules, Molecular Sequence Data, Neurofibrillary Tangles - metabolism, Paired helical filament, Proteins, tau protein, tau Proteins - metabolism, tau Proteins - ultrastructure