Details

Autor(en) / Beteiligte

• BURN, D. J
• WATSON, J. D. G
• RODDIE, M
• CHU, A. C
• LEGG, N. J
• FRACKOWIAK, R. S. J

Titel

Langerhans' cell histiocytosis and the nervous system

Ist Teil von

• Journal of neurology, 1992-07, Vol.239 (6), p.345-350

Ort / Verlag

Berlin: Springer

Erscheinungsjahr

1992

Quelle

MEDLINE

Beschreibungen/Notizen

• We report two cases of Langerhans' cell histiocytosis with unusual central nervous system (CNS) involvement. The first patient had behavioural disturbances, memory loss and diabetes insipidus. His response to a range of treatments was poor. The second patient presented with seizures and headaches suggestive of raised intracranial pressure. Etoposide (VP16) chemotherapy led to a dramatic clinical and radiological improvement. The various CNS manifestations of Langerhans' cell histiocytosis and their management are discussed.