Nature neuroscience, 2003-04, Vol.6 (4), p.384-390
2003
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- Autor(en) / Beteiligte
- Titel
- Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
- Ist Teil von
- Nature neuroscience, 2003-04, Vol.6 (4), p.384-390
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2003
- Quelle
- Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylation of cyclic AMP-responsive element binding protein (CREB), and MAP kinase inhibitors blocked these inductions. An increase in CREB phosphorylation and L-LTP induced by one-train tetanus were observed in the multiparous mouse hippocampus without oxytocin application. Furthermore, intracerebroventricular injection of oxytocin in virgin mice improved long-term spatial learning in vivo, whereas an injection of oxytocin antagonist in multiparous mice significantly inhibited the improved spatial memory, L-LTP and CREB phosphorylation. These findings indicate that oxytocin is critically involved in improving hippocampus-dependent learning and memory during motherhood in mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn1023Titel-ID: cdi_proquest_miscellaneous_73143066
- Format
- –
- Schlagworte
- Animals, Breastfeeding & lactation, Cyclic AMP Response Element-Binding Protein - drug effects, Cyclic AMP Response Element-Binding Protein - metabolism, Electric Stimulation, Enzyme Inhibitors - pharmacology, Hippocampus - drug effects, Hippocampus - enzymology, Hormones, Hypothalamus, Injections, Intraventricular, Kinases, Lactation - drug effects, Lactation - physiology, Learning - drug effects, Learning - physiology, Long-Term Potentiation - drug effects, Long-Term Potentiation - physiology, MAP Kinase Signaling System - drug effects, MAP Kinase Signaling System - physiology, Maternal Behavior - drug effects, Maternal Behavior - physiology, Memory, Memory - drug effects, Memory - physiology, Mice, Neural Pathways - drug effects, Neural Pathways - enzymology, Neurons - drug effects, Neurons - enzymology, Organ Culture Techniques, Oxytocin, Oxytocin - antagonists & inhibitors, Oxytocin - metabolism, Phosphorylation, Phosphorylation - drug effects, Physiological aspects, Protein kinases, Space Perception - drug effects, Space Perception - physiology, Tetanus, Up-Regulation - drug effects, Up-Regulation - physiology