Details

Autor(en) / Beteiligte

• Sugihara, Nobuyuki
• Matsuzaki, Masunori
• Kato, Yukiko

Titel

The Relation between Bone Calcium Metabolism and Senile Aortic Valve Calcification

Ist Teil von

• Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1992/05/25, Vol.29(5), pp.403-410

Ort / Verlag

Japan: The Japan Geriatrics Society

Erscheinungsjahr

1992

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The authors assessed the affect of bone calcium metabolism on aortic valve calcification (AVC) in 189 septua- and octogenarians (49 males and 140 females, 81.0±4.4yrs). Both AVC and mitral annular calcification (MAC) were evaluated by two-dimensional echocardiography, and then the degree of AVC was classified into three categories; C-1: calcification seen in one cusp of the aortic valve, C-2: calcification in two cusps, and C-3: calcification in three cusps. Bone mineral content (BMC) of three lumbar vertebral bodies was obtained by quantitative computed tomography using a calibrated phantom. Serum calcium, phosphate, parathyroid hormone, calcitonin, and osteocalcin were also examined within a month. The patients were classified into age-matched five groups in both sexes; Group-C: MAC (-) and AVC (-) (n=79); Group-A1: MAC (-) and AVC (+) with C-1 (n=35); Group-A2: MAC (-) and AVC (+) with C-2 (n=19); Group-A3: MAC (-) and AVC (+) with C-3 (n=15); and Group-AM: MAC (+) and AVC (+) in any cusp (n=42). In males, BMC decreased in the order of Groups-A3 (83±27mg/cm3), -C(67±50), -AM(62±62), -A2 (61±38), and -A1 (59±58), but there was no significant difference between any of the five groups. In females, the BMC in Group-AM (29±24) was significantly less than that in Group-C (48±35) (p<0.05). There was no difference in BMC between Groups-A1 (44±33), -A2 (52±36), -A3 (42±32) and -C. In both sexes, serum examinations showed no significant differences between the five groups. It was concluded that AVC was not related to bone calcium metabolism in either sex, and that there was no significant relation between the incidence of intracardiac calcification and the humoral factors related to calcium metabolism, and furthermore, that AVC might be mainly caused by other factors, such as blood pressure or stress loading.