Brain research, 1992-07, Vol.586 (1), p.117-120
1992
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Details
- Autor(en) / Beteiligte
- Titel
- Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases β-adrenoceptor-linked cyclic AMP formation in middle-aged rats
- Ist Teil von
- Brain research, 1992-07, Vol.586 (1), p.117-120
- Ort / Verlag
- London: Elsevier B.V
- Erscheinungsjahr
- 1992
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- The possible involvement of β-adrenoceptor system in the effectiveness of 9-amino-1,2,3,4-tetrahydroacridine (THA) to attenuate retention deficits exhibited by middle-aged rats in a one-trial passive avoidance task has been investigated. THA (2.5 mg·kg −1), injected i.p. after training, induced a significant increase in test step-through latency (STL) in middle-aged rats. Post-training injection of THA reduced basal and isoprenaline stimulated cyclic AMP accumulation in cortex and hippocampus of every group of rats. It is suggested that the effect of THA on memory processes may involve an action on β-adrenoceptor-linked cyclic AMP accumulation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-8993eISSN: 1872-6240DOI: 10.1016/0006-8993(92)91379-STitel-ID: cdi_proquest_miscellaneous_73138673
- Format
- –
- Schlagworte
- 1-Methyl-3-isobutylxanthine - pharmacology, Adenylate cyclase, Aging, Aging - metabolism, Aging - physiology, Animals, Avoidance Learning - drug effects, Biological and medical sciences, Cerebral Cortex - metabolism, Conditioning (Psychology), Cortex, Cyclic AMP - biosynthesis, Electroshock, Foot, Fundamental and applied biological sciences. Psychology, Hippocampus, Hippocampus - metabolism, Isoproterenol - pharmacology, Learning. Memory, Male, Memory - drug effects, Miscellaneous, Passive avoidance, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Rats, Rats, Inbred Strains, Receptors, Adrenergic, beta - physiology, Tacrine - pharmacology, Tetrahydroaminoacridine, β-Adrenoceptor